How does LYFGENIA™ work?

LYFGENIA is a gene addition therapy designed to add genetic material to your cells
through a viral vector.

Learn how LYFGENIA works at the genetic level—from collecting your blood stem cells to
adding new modified cells to your body.

Blood stem cells are collected from your body

First, cells are collected

Blood stem cells are collected from your body through mobilization and apheresis

Blood stem cells are collected from your body

First, cells are collected

Blood stem cells are collected from your body through mobilization and apheresis

LYFGENIA is created by adding working copies of the beta-globin gene to your blood stem cells via a viral vector

Then, cells are modified

LYFGENIA is created by adding working copies of the HBB (beta-globin) gene to your collected cells through a viral vector

LYFGENIA is created by adding working copies of the beta-globin gene to your blood stem cells via a viral vector

Then, cells are modified

LYFGENIA is created by adding working copies of the HBB (beta-globin) gene to your collected cells through a viral vector

Your modified cells (LYFGENIA) are administered through an IV infusion

Next, LYFGENIA
is infused

Your modified cells (LYFGENIA) are returned to your body through an infusion

Your modified cells (LYFGENIA) are administered through an IV infusion

Next, LYFGENIA
is infused

Your modified cells (LYFGENIA) are returned to your body through an infusion

Modified blood stem cells go through engraftment, leading to the production of new red blood cells containing functional adult hemoglobin

Functional adult
hemoglobin is produced

Your modified cells go through a process called engraftment, which leads to the production of new red blood cells containing functional adult hemoglobin

Modified blood stem cells go through engraftment, leading to the production of new red blood cells containing functional adult hemoglobin

Functional adult
hemoglobin is produced

Your modified cells go through a process called engraftment, which leads to the production of new red blood cells containing functional adult hemoglobin

Blood stem cells are collected from your body

First, cells are collected

Blood stem cells are collected from your body through mobilization and apheresis

Blood stem cells are collected from your body

First, cells are collected

Blood stem cells are collected from your body through mobilization and apheresis

LYFGENIA is created by adding working copies of the beta-globin gene to your blood stem cells via a viral vector

Then, cells are modified

LYFGENIA is created by adding working copies of the HBB (beta-globin) gene to your collected cells through a viral vector

LYFGENIA is created by adding working copies of the beta-globin gene to your blood stem cells via a viral vector

Then, cells are modified

LYFGENIA is created by adding working copies of the HBB (beta-globin) gene to your collected cells through a viral vector

Your modified cells (LYFGENIA) are administered through an IV infusion

Next, LYFGENIA
is infused

Your modified cells (LYFGENIA) are returned to your body through an infusion

Your modified cells (LYFGENIA) are administered through an IV infusion

Next, LYFGENIA
is infused

Your modified cells (LYFGENIA) are returned to your body through an infusion

Modified blood stem cells go through engraftment, leading to the production of new red blood cells containing functional adult hemoglobin

Functional adult
hemoglobin is produced

Your modified cells go through a process called engraftment, which leads to the production of new red blood cells containing functional adult hemoglobin

Modified blood stem cells go through engraftment, leading to the production of new red blood cells containing functional adult hemoglobin

Functional adult
hemoglobin is produced

Your modified cells go through a process called engraftment, which leads to the production of new red blood cells containing functional adult hemoglobin

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Want to know more about how LYFGENIA is delivered into the cells in your body?

It’s important to understand how viral vectorsA delivery system used to introduce genetic material into the cells work.
Learn more about vectors
More topics to explore More topics to explore
LYFGENIA Results
The Steps to Treatment