Partner with your healthcare team
Partner with your healthcare team
When considering LYFGENIA, you should make sure to work closely with your team, including regular physicians and genegeneA sequence of DNA responsible for controlling inherited traits therapy specialists, to determine whether gene therapy is the right choice for you and your family.
Planning plays a big part in this, from healthcare coverage and impacts on daily life (including work and family responsibilities) to chemotherapy and fertility discussions.
A breakdown of the treatment process with LYFGENIA
A breakdown of the treatment process with LYFGENIA
Explore the 6 key steps
Explore the 6 key steps
Before we talk treatment, it’s important to keep in mind that these time frames are meant as an approximate guideline. Your journey may look different depending on you, your circumstances, and your care team at the QTC.
STEP 1
Pre-treatment
Before you begin LYFGENIA, it’s important you talk to your doctor about all of the medicines involved and why blood transfusions are required.
STEP 2*
Stem Cell Collection
(~1 week at the QTC)
For stem cell collection, you’ll need mobilizationmobilizationThe first part of the stem cell collection process, moving stem cells out of the bone marrow and into the circulating blood and apheresisapheresisPart of the stem cell collection process that involves separating blood stem cells from blood cells using a machine.
*This step may need to be repeated.
STEP 3
LYFGENIA Creation
(10-15 weeks)
After stem cell collection, your cells will be sent to a manufacturing site to create LYFGENIA.
STEP 4
Conditioning Chemotherapy
(4 days + ≥2 days of recovery at the QTC)
During this stage, your body will be conditionedconditionedThe process of making room in your bone marrow for gene therapy or a stem cell transplant through chemotherapy. Conditioning is required for all transplant options—whether it’s gene therapy or a donor stem cell transplant with chemotherapy to make room in your bone marrow for LYFGENIA.
STEP 5
LYFGENIA Infusion
(~30 minutes per bag at QTC)
After conditioning, you will receive LYFGENIA through an IV infusioninfusionThe process by which LYFGENIA is administered into your veins. You may receive anywhere from 1 to 4 bags.
STEP 6
Recovery & Long-term Follow-up
(~3-6 weeks of monitoring at the QTC followed by long-term follow-up for at least 15 years)
After your LYFGENIA infusion, you’ll be monitored at the QTC and work with your team to make a follow-up monitoring plan.
STEP 1
Pre-treatment
Before you begin LYFGENIA, it’s important you talk to your doctor about all of the medicines involved and why blood transfusions are required.
STEP 2*
Stem Cell Collection
(~1 week at the QTC)
For stem cell collection, you’ll need mobilizationmobilizationThe first part of the stem cell collection process, moving stem cells out of the bone marrow and into the circulating blood and apheresisapheresisPart of the stem cell collection process that involves separating blood stem cells from blood cells using a machine.
*This step may need to be repeated.
STEP 3
LYFGENIA Creation
(10-15 weeks)
After stem cell collection, your cells will be sent to a manufacturing site to create LYFGENIA.
STEP 4
Conditioning Chemotherapy
(4 days + ≥2 days of recovery at the QTC)
During this stage, your body will be conditionedconditionedThe process of making room in your bone marrow for gene therapy or a stem cell transplant through chemotherapy. Conditioning is required for all transplant options—whether it’s gene therapy or a donor stem cell transplant with chemotherapy to make room in your bone marrow for LYFGENIA.
STEP 5
LYFGENIA Infusion
(~30 minutes per bag at QTC)
After conditioning, you will receive LYFGENIA through an IV infusioninfusionThe process by which LYFGENIA is administered into your veins. You may receive anywhere from 1 to 4 bags.
STEP 6
Recovery & Long-term Follow-up
(~3-6 weeks of monitoring at the QTC followed by long-term follow-up for at least 15 years)
After your LYFGENIA infusion, you’ll be monitored at the QTC and work with your team to make a follow-up monitoring plan.
