Safety of LYFGENIA™

What are the side effects?

What is the most important information I should know about LYFGENIA?

Individuals treated with LYFGENIA have developed blood cancers. Treatment with LYFGENIA may increase your risk of developing blood cancer. Blood cancer can develop many years after treatment with LYFGENIA. Blood cancer can be life-threatening and/or cause death.

Because of the risk of blood cancer, you should talk to your doctor about the benefits and risks of LYFGENIA, and about your treatment options. Your doctor may evaluate if you have risk factors that increase your chances of developing blood cancer after LYFGENIA.

Because of the risk of cancer, it is important for you to be monitored at least every 6 months for a minimum of 15 years after LYFGENIA.

Monitoring will include blood tests that measure your blood cell counts and evaluation of the blood cells where the gene product is present with specialized tests. If these tests are abnormal, additional testing may be recommended by your doctor. Additional testing might include more frequent blood tests to watch you more closely for changes in your blood. Additional testing could also include a bone marrow evaluation, which can tell your doctor if a blood cancer is developing.

If you are diagnosed with a cancer, have your treating physician contact bluebird bio at 1-833-999-6378.

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The possible side effects include:

On the day of treatment with LYFGENIA

  • Low blood pressure
  • Hot flush

Following LYFGENIA

  • Blood cancers
  • Longer time for platelets (cells in your blood that bind together to stop bleeding) to recover, which may reduce the ability for blood to clot and may cause bleeding

These are not all the possible side effects of LYFGENIA. Talk to a doctor about the possible side effects before treatment.

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